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Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans

Enantioselective synthesis of chiral isochromans bearing a terminal alkyne moiety has been accomplished by copper-catalysed enantioselective intramolecular propargylic substitution reactions of propargylic esters with alcoholic nucleophiles. This method represents the first successful example which...

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Detalles Bibliográficos
Autores principales: Liu, Shiyao, Nakajima, Kazunari, Nishibayashi, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065272/
https://www.ncbi.nlm.nih.gov/pubmed/35516894
http://dx.doi.org/10.1039/c9ra03880a