Restoration of Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca(2+) Depletion

Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca(2+)) from cytosol into the lumen of the endoplas...

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Detalles Bibliográficos
Autores principales: Zhang, Wen, Ye, Fanghua, Pang, Nan, Kessi, Miriam, Xiong, Juan, Chen, Shimeng, Peng, Jing, Yang, Li, Yin, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065279/
https://www.ncbi.nlm.nih.gov/pubmed/35517826
http://dx.doi.org/10.3389/fphar.2022.877175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065279/
https://www.ncbi.nlm.nih.gov/pubmed/35517826
http://dx.doi.org/10.3389/fphar.2022.877175

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