Brain Cells Release Calreticulin That Attracts and Activates Microglia, and Inhibits Amyloid Beta Aggregation and Neurotoxicity

Calreticulin is a chaperone, normally found in the endoplasmic reticulum, but can be released by macrophages into the extracellular medium. It is also found in cerebrospinal fluid bound to amyloid beta (Aβ). We investigated whether brain cells release calreticulin, and whether extracellular calretic...

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Detalles Bibliográficos
Autores principales: Reid, Kyle M., Kitchener, Emily J. A., Butler, Claire A., Cockram, Tom O. J., Brown, Guy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065406/
https://www.ncbi.nlm.nih.gov/pubmed/35514983
http://dx.doi.org/10.3389/fimmu.2022.859686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065406/
https://www.ncbi.nlm.nih.gov/pubmed/35514983
http://dx.doi.org/10.3389/fimmu.2022.859686

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