Glucose inhibits glucagon secretion by decreasing [Ca(2+)](c) and by reducing the efficacy of Ca(2+) on exocytosis via somatostatin-dependent and independent mechanisms

OBJECTIVE: The mechanisms by which glucose stimulates insulin secretion from β-cells are well established and involve inhibition of ATP-sensitive K(+) (K(ATP)) channels, followed by a rise in [Ca(2+)](c) that triggers exocytosis. However, the mechanisms by which glucose controls glucagon release fro...

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Detalles Bibliográficos
Autores principales: Singh, Bilal, Khattab, Firas, Gilon, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065434/
https://www.ncbi.nlm.nih.gov/pubmed/35421610
http://dx.doi.org/10.1016/j.molmet.2022.101495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065434/
https://www.ncbi.nlm.nih.gov/pubmed/35421610
http://dx.doi.org/10.1016/j.molmet.2022.101495

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