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Glucose inhibits glucagon secretion by decreasing [Ca(2+)](c) and by reducing the efficacy of Ca(2+) on exocytosis via somatostatin-dependent and independent mechanisms
OBJECTIVE: The mechanisms by which glucose stimulates insulin secretion from β-cells are well established and involve inhibition of ATP-sensitive K(+) (K(ATP)) channels, followed by a rise in [Ca(2+)](c) that triggers exocytosis. However, the mechanisms by which glucose controls glucagon release fro...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065434/ https://www.ncbi.nlm.nih.gov/pubmed/35421610 http://dx.doi.org/10.1016/j.molmet.2022.101495 |