Microwave-assisted organic synthesis of nucleoside ProTide analogues

A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5′-phosphoramidate synthesis, without protection...

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Detalles Bibliográficos
Autores principales: Bordoni, Cinzia, Cima, Cecilia Maria, Azzali, Elisa, Costantino, Gabriele, Brancale, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065484/
https://www.ncbi.nlm.nih.gov/pubmed/35514718
http://dx.doi.org/10.1039/c9ra01754b
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author Bordoni, Cinzia
Cima, Cecilia Maria
Azzali, Elisa
Costantino, Gabriele
Brancale, Andrea
author_facet Bordoni, Cinzia
Cima, Cecilia Maria
Azzali, Elisa
Costantino, Gabriele
Brancale, Andrea
author_sort Bordoni, Cinzia
collection PubMed
description A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5′-phosphoramidate synthesis, without protection of the 3′ position in the ribonucleoside.
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spelling pubmed-90654842022-05-04 Microwave-assisted organic synthesis of nucleoside ProTide analogues Bordoni, Cinzia Cima, Cecilia Maria Azzali, Elisa Costantino, Gabriele Brancale, Andrea RSC Adv Chemistry A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5′-phosphoramidate synthesis, without protection of the 3′ position in the ribonucleoside. The Royal Society of Chemistry 2019-06-27 /pmc/articles/PMC9065484/ /pubmed/35514718 http://dx.doi.org/10.1039/c9ra01754b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Bordoni, Cinzia
Cima, Cecilia Maria
Azzali, Elisa
Costantino, Gabriele
Brancale, Andrea
Microwave-assisted organic synthesis of nucleoside ProTide analogues
title Microwave-assisted organic synthesis of nucleoside ProTide analogues
title_full Microwave-assisted organic synthesis of nucleoside ProTide analogues
title_fullStr Microwave-assisted organic synthesis of nucleoside ProTide analogues
title_full_unstemmed Microwave-assisted organic synthesis of nucleoside ProTide analogues
title_short Microwave-assisted organic synthesis of nucleoside ProTide analogues
title_sort microwave-assisted organic synthesis of nucleoside protide analogues
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065484/
https://www.ncbi.nlm.nih.gov/pubmed/35514718
http://dx.doi.org/10.1039/c9ra01754b
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AT costantinogabriele microwaveassistedorganicsynthesisofnucleosideprotideanalogues
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