The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signalling

The homologous proteins Gas6 and protein S (ProS1) are both natural ligands for the TAM (Tyro3, Axl, MerTK) receptor tyrosine kinases. ProS1 selectively activates Tyro3; however, the precise molecular interface of the ProS1-Tyro3 contact has not been characterised. We used a set of chimeric proteins...

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Detalles Bibliográficos
Autores principales: Al Kafri, Nour, Ahnström, Josefin, Teraz-Orosz, Adrienn, Chaput, Ludovic, Singh, Natesh, Villoutreix, Bruno O., Hafizi, Sassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065593/
https://www.ncbi.nlm.nih.gov/pubmed/35518197
http://dx.doi.org/10.1016/j.bbrep.2022.101263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065593/
https://www.ncbi.nlm.nih.gov/pubmed/35518197
http://dx.doi.org/10.1016/j.bbrep.2022.101263

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