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The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signalling
The homologous proteins Gas6 and protein S (ProS1) are both natural ligands for the TAM (Tyro3, Axl, MerTK) receptor tyrosine kinases. ProS1 selectively activates Tyro3; however, the precise molecular interface of the ProS1-Tyro3 contact has not been characterised. We used a set of chimeric proteins...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065593/ https://www.ncbi.nlm.nih.gov/pubmed/35518197 http://dx.doi.org/10.1016/j.bbrep.2022.101263 |