Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation. Silenced GSDME expression due to promoter hypermethylation is associated with gastric cancer (GC), which is confirmed in the present stud...

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Detalles Bibliográficos
Autores principales: Xia, Ying, Jin, Yong, Cui, Daxiang, Wu, Xia, Song, Cunfeng, Jin, Weilin, Huang, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065610/
https://www.ncbi.nlm.nih.gov/pubmed/35517821
http://dx.doi.org/10.3389/fphar.2022.860546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065610/
https://www.ncbi.nlm.nih.gov/pubmed/35517821
http://dx.doi.org/10.3389/fphar.2022.860546

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