Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy

Pancreatic β-cells express ATP-sensitive potassium (K(ATP)) channels, consisting of octamer complexes containing four sulfonylurea receptor 1 (SUR1) and four Kir6.2 subunits. Loss of K(ATP) channel function causes persistent hyperinsulinemic hypoglycemia of infancy (PHHI), a rare but debilitating co...

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Detalles Bibliográficos
Autores principales: Lin, Ching-Han, Lin, Yu-Chi, Yang, Shi-Bing, Chen, Pei-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065613/
https://www.ncbi.nlm.nih.gov/pubmed/35398096
http://dx.doi.org/10.1016/j.jbc.2022.101904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065613/
https://www.ncbi.nlm.nih.gov/pubmed/35398096
http://dx.doi.org/10.1016/j.jbc.2022.101904

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