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Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study

This study determines the effect of cookies made from sea grapes (Caulerpa racemosa) on PGC-1α, total cholesterol, and blood glucose levels on mice fed with a Cholesterol- and Fat-Enriched Diet (CFED). The antioxidant activity, tyrosinase inhibition, α-glucosidase, and α-amylase inhibition is also a...

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Autores principales: Ngadiarti, Iskari, Nurkolis, Fahrul, Handoko, Matthew Nathaniel, Perdana, Fachruddin, Permatasari, Happy Kurnia, Taslim, Nurpudji Astuti, Mayulu, Nelly, Wewengkang, Defny Silvia, Noor, Sutamara Lasurdi, Batubara, Siti Chairiyah, Tanner, Melvin Junior, Sabrina, Nindy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065618/
https://www.ncbi.nlm.nih.gov/pubmed/35521505
http://dx.doi.org/10.1016/j.heliyon.2022.e09348
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author Ngadiarti, Iskari
Nurkolis, Fahrul
Handoko, Matthew Nathaniel
Perdana, Fachruddin
Permatasari, Happy Kurnia
Taslim, Nurpudji Astuti
Mayulu, Nelly
Wewengkang, Defny Silvia
Noor, Sutamara Lasurdi
Batubara, Siti Chairiyah
Tanner, Melvin Junior
Sabrina, Nindy
author_facet Ngadiarti, Iskari
Nurkolis, Fahrul
Handoko, Matthew Nathaniel
Perdana, Fachruddin
Permatasari, Happy Kurnia
Taslim, Nurpudji Astuti
Mayulu, Nelly
Wewengkang, Defny Silvia
Noor, Sutamara Lasurdi
Batubara, Siti Chairiyah
Tanner, Melvin Junior
Sabrina, Nindy
author_sort Ngadiarti, Iskari
collection PubMed
description This study determines the effect of cookies made from sea grapes (Caulerpa racemosa) on PGC-1α, total cholesterol, and blood glucose levels on mice fed with a Cholesterol- and Fat-Enriched Diet (CFED). The antioxidant activity, tyrosinase inhibition, α-glucosidase, and α-amylase inhibition is also analyzed in order to assess the in vitro anti-aging potential of sea grapes cookies. Forty male Mus muscullus albino mice weighing 20 g–30 g were used and randomly distributed into four groups of ten animals each. Group A served as a normal control (given a standard dry pellet diet), Group B was given CFED only, and mice in Groups C and D were given CFED with 100 mg and 200 mg/20 g body weight of sea grapes cookies, respectively for 4 weeks. In vitro study shows that the percentage of inhibition activity of antioxidant, L-Tyrosine, L-Dopa, α-glucosidase, and α-amylase inhibition were 45.65 ± 1.50, 8.95 ± 0.06, 21.31 ± 0.98, 77.12 ± 4.67 and 70.94 ± 0.98, respectively. This study found that group D had better activity in lowering blood glucose than group C (p < 0.0001). In addition, although there was not found significant difference between groups C and D in blood cholesterol reduction and PGC-1α (p = 0.1482), both groups experienced the same effect in total cholesterol reduction and PGC-1α in mice (significantly, p < 0001). Thus, we conclude that sea grapes cookies are proven to improve PGC-1α, total cholesterol, and blood glucose levels in mice fed with CFED. Hence, sea grapes cookies is a potential anti-aging novel-functional food.
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spelling pubmed-90656182022-05-04 Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study Ngadiarti, Iskari Nurkolis, Fahrul Handoko, Matthew Nathaniel Perdana, Fachruddin Permatasari, Happy Kurnia Taslim, Nurpudji Astuti Mayulu, Nelly Wewengkang, Defny Silvia Noor, Sutamara Lasurdi Batubara, Siti Chairiyah Tanner, Melvin Junior Sabrina, Nindy Heliyon Research Article This study determines the effect of cookies made from sea grapes (Caulerpa racemosa) on PGC-1α, total cholesterol, and blood glucose levels on mice fed with a Cholesterol- and Fat-Enriched Diet (CFED). The antioxidant activity, tyrosinase inhibition, α-glucosidase, and α-amylase inhibition is also analyzed in order to assess the in vitro anti-aging potential of sea grapes cookies. Forty male Mus muscullus albino mice weighing 20 g–30 g were used and randomly distributed into four groups of ten animals each. Group A served as a normal control (given a standard dry pellet diet), Group B was given CFED only, and mice in Groups C and D were given CFED with 100 mg and 200 mg/20 g body weight of sea grapes cookies, respectively for 4 weeks. In vitro study shows that the percentage of inhibition activity of antioxidant, L-Tyrosine, L-Dopa, α-glucosidase, and α-amylase inhibition were 45.65 ± 1.50, 8.95 ± 0.06, 21.31 ± 0.98, 77.12 ± 4.67 and 70.94 ± 0.98, respectively. This study found that group D had better activity in lowering blood glucose than group C (p < 0.0001). In addition, although there was not found significant difference between groups C and D in blood cholesterol reduction and PGC-1α (p = 0.1482), both groups experienced the same effect in total cholesterol reduction and PGC-1α in mice (significantly, p < 0001). Thus, we conclude that sea grapes cookies are proven to improve PGC-1α, total cholesterol, and blood glucose levels in mice fed with CFED. Hence, sea grapes cookies is a potential anti-aging novel-functional food. Elsevier 2022-04-28 /pmc/articles/PMC9065618/ /pubmed/35521505 http://dx.doi.org/10.1016/j.heliyon.2022.e09348 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Ngadiarti, Iskari
Nurkolis, Fahrul
Handoko, Matthew Nathaniel
Perdana, Fachruddin
Permatasari, Happy Kurnia
Taslim, Nurpudji Astuti
Mayulu, Nelly
Wewengkang, Defny Silvia
Noor, Sutamara Lasurdi
Batubara, Siti Chairiyah
Tanner, Melvin Junior
Sabrina, Nindy
Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study
title Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study
title_full Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study
title_fullStr Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study
title_full_unstemmed Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study
title_short Anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study
title_sort anti-aging potential of cookies from sea grapes in mice fed on cholesterol- and fat-enriched diet: in vitro with in vivo study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065618/
https://www.ncbi.nlm.nih.gov/pubmed/35521505
http://dx.doi.org/10.1016/j.heliyon.2022.e09348
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