Solution structure ensemble of human obesity-associated protein FTO reveals druggable surface pockets at the interface between the N- and C-terminal domain

The fat mass and obesity-associated FTO protein catalyzes demethylation of the N(6)-methyladenosine, an epigenetic mark that controls several metabolic pathways by modulating the transcription, translation, and cellular localization of RNA molecules. Since the discovery that its overexpression links...

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Detalles Bibliográficos
Autores principales: Khatiwada, Balabhadra, Nguyen, Trang T., Purslow, Jeffrey A., Venditti, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065727/
https://www.ncbi.nlm.nih.gov/pubmed/35398093
http://dx.doi.org/10.1016/j.jbc.2022.101907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065727/
https://www.ncbi.nlm.nih.gov/pubmed/35398093
http://dx.doi.org/10.1016/j.jbc.2022.101907

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