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Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2

The active sites of the proteasome are housed within its central core particle (CP), a barrel-shaped chamber of four stacked heptameric rings, and access of substrates to the CP interior is mediated by gates at either axial end. These gates are constitutively closed and may be opened by the regulato...

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Detalles Bibliográficos
Autores principales: Schnell, Helena M., Ang, Jessie, Rawson, Shaun, Walsh, Richard M., Micoogullari, Yagmur, Hanna, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065996/
https://www.ncbi.nlm.nih.gov/pubmed/35398095
http://dx.doi.org/10.1016/j.jbc.2022.101906