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Downregulation of MTAP promotes Tumor Growth and Metastasis by regulating ODC Activity in Breast Cancer
5'-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway and has been reported to suppress tumorigenesis. The MTAP gene is located at 9p21, a chromosome region often deleted in breast cancer (BC). However, the clinical and biological significance of MTAP in...
Autores principales: | Zhang, Ying, Zhang, Tian-Tian, Gao, Lin, Tan, Ya-Nan, Li, Yu-Ting, Tan, Xiang-Yu, Huang, Tu-Xiong, Li, Hua-Hui, Bai, Feng, Zou, Chang, Pei, Xin-Hai, Tan, Bin-Bin, Fu, Li |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066107/ https://www.ncbi.nlm.nih.gov/pubmed/35541910 http://dx.doi.org/10.7150/ijbs.67149 |
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