Cargando…
Toosendanin, a novel potent vacuolar-type H(+)-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy
Macroautophagy/autophagy is the process of self-digestion through the lysosomes; it disassembles unnecessary or dysfunctional long-lived proteins and damaged organelles for the recycling of biomacromolecules. Unfortunately, cancer cells can hijack this mechanism to survive under metabolic stress or...
Autores principales: | Dong, Yu, Zhu, Guoyuan, Wang, Sheng-Fang, Keon, Kristine A., Rubinstein, John L., Zeng, Si-Xin, Zhang, Shuang, Chen, Qiu-Ling, Fu, Jing, Li, Min, Shen, Han-Ming, Lu, Jin-Jian, Chen, Xiu-Ping, Lu, Jia-Hong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066121/ https://www.ncbi.nlm.nih.gov/pubmed/35541921 http://dx.doi.org/10.7150/ijbs.71041 |
Ejemplares similares
-
Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy
por: Zhang, Shuang, et al.
Publicado: (2022) -
Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
por: Hayek, Summer R., et al.
Publicado: (2014) -
A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival
por: Paha, Jiraporn, et al.
Publicado: (2019) -
Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases
por: Mazhab-Jafari, Mohammad T., et al.
Publicado: (2016) -
Vacuolar proton-translocating ATPase is required for antifungal resistance and virulence of Candida glabrata
por: Minematsu, Asuka, et al.
Publicado: (2019)