Cargando…

Design and synthesis of novel phenylaminopyrimidines with antiproliferative activity against colorectal cancer

New phenylaminopyrimidine (PAP) derivatives have been designed and synthesised as potential tyrosine kinase inhibitors for the treatment of cancer. The synthesized compounds share a general structure and vary in the substitution pattern at position-2 of the pyridine ring. Several derivatives have de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Henidi, Hanan A., Al-Abd, Ahmed M., Al-Abbasi, Fahad A., BinMahfouz, Hawazen A., El-Deeb, Ibrahim M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066187/ https://www.ncbi.nlm.nih.gov/pubmed/35521305 http://dx.doi.org/10.1039/c9ra03359a

Ejemplares similares

Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells
por: Chang, Sheng, et al.
Publicado: (2009)

Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity
por: Henidi, Hanan A., et al.
Publicado: (2020)

Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells
por: Al-Qahtani, Salwa D., et al.
Publicado: (2022)

Correction: Al-Qahtani et al. Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells. Life 2022, 12, 1369
por: Al-Qahtani, Salwa D., et al.
Publicado: (2023)

Design, Synthesis, and Antiproliferative Activity of Novel Neocryptolepine–Rhodanine Hybrids
por: El-Bahnsawye, Mohamed, et al.
Publicado: (2022)

Design and Synthesis of New Thiophene/Thieno[2,3-d]pyrimidines along with Their Cytotoxic Biological Evaluation as Tyrosine Kinase Inhibitors in Addition to Their Apoptotic and Autophagic Induction
por: Elmongy, Elshaymaa I., et al.
Publicado: (2021)

Design, synthesis and antiproliferative screening of newly synthesized acrylate derivatives as potential anticancer agents
por: Alshaya, Dalal Sulaiman, et al.
Publicado: (2023)

New Quinoxaline-Based Derivatives as PARP-1 Inhibitors: Design, Synthesis, Antiproliferative, and Computational Studies
por: Syam, Yasmin M., et al.
Publicado: (2022)

Design, Synthesis, Docking Study, and Antiproliferative Evaluation of Novel Schiff Base–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity
por: Abd El-Lateef, Hany M., et al.
Publicado: (2023)

Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation
por: Eldehna, Wagdy M., et al.
Publicado: (2020)

Facile synthesis and antiproliferative activity of new 3-cyanopyridines
por: Abdel-aziz, Hassan M., et al.
Publicado: (2019)

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2022)

Design, synthesis and antiproliferative screening of newly synthesized coumarin-acrylamide hybrids as potential cytotoxic and apoptosis inducing agents
por: Abd El-Lateef, Hany M., et al.
Publicado: (2023)

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones
por: Onnis, Valentina, et al.
Publicado: (2016)

New Zampanolide Mimics: Design, Synthesis, and Antiproliferative Evaluation
por: Chen, Guanglin, et al.
Publicado: (2020)

Design, Synthesis, Anticancer Evaluation and Molecular Modeling of Novel Estrogen Derivatives
por: Amr, Abd El-Galil E., et al.
Publicado: (2019)

Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study
por: Fares, Salma, et al.
Publicado: (2021)

Synthesis of new thienylpicolinamidine derivatives and possible mechanisms of antiproliferative activity
por: Ismail, Mohamed A., et al.
Publicado: (2020)

Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity
por: Ibrahim, Tarek S., et al.
Publicado: (2020)

Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus
por: Elhady, Sameh S., et al.
Publicado: (2016)

Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds
por: Gupta, Shilpi, et al.
Publicado: (2023)

Synthesis and Characterization of New Series of 1,3-5-Triazine Hydrazone Derivatives with Promising Antiproliferative Activity
por: Al Rasheed, Hessa H., et al.
Publicado: (2020)

Synthesis and antiproliferative assay of triazolyl-2,2-dimethyl-3-phenylpropanoates as potential HDAC inhibitors
por: El-Rayes, Samir, et al.
Publicado: (2019)

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF(V600E) Dual Inhibitors Endowed with Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAF(V600E)
por: Alshammari, Mohammed B., et al.
Publicado: (2022)

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties
por: Choura, Emna, et al.
Publicado: (2022)

Design and Synthesis of Novel Dehydroepiandrosterone Analogues as Potent Antiproliferative Agents
por: Huang, Xing, et al.
Publicado: (2018)

Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity
por: Reddy, Kachi R. Kishore Kumar, et al.
Publicado: (2012)

Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study
por: El-Sayed, Amira A., et al.
Publicado: (2019)

Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents
por: Al-blewi, Fawzia Faleh, et al.
Publicado: (2018)

In Vitro and In Silico Evaluation of Antiproliferative Activity of New Isoxazolidine Derivatives Targeting EGFR: Design, Synthesis, Cell Cycle Analysis, and Apoptotic Inducers
por: Alminderej, Fahad, et al.
Publicado: (2023)

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation
por: Taghour, Mohammed S., et al.
Publicado: (2022)

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines
por: Youssef, Magdy M, et al.
Publicado: (2016)

Design, Synthesis and Antiproliferative Activity of Novel 2-Substituted-4-amino-6-halogenquinolines
por: Jiang, Nan, et al.
Publicado: (2012)

New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
por: Alanazi, Mohammed M., et al.
Publicado: (2021)

1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies
por: Hagras, Mohamed, et al.
Publicado: (2021)

Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents
por: Al-Sanea, Mohammad M., et al.
Publicado: (2015)

In-Silico Screening of Novel Synthesized Thienopyrimidines Targeting Fms Related Receptor Tyrosine Kinase-3 and Their In-Vitro Biological Evaluation
por: Elmongy, Elshaymaa I., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g99jolfdanm6pei75dfb1kp20e