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Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications
The cellular level of TDP-43 (also known as TARDBP) is tightly regulated; increases or decreases in TDP-43 have deleterious effects in cells. The predominant mechanism responsible for the regulation of the level of TDP-43 is an autoregulatory negative feedback loop. In this study, we identified an i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066495/ https://www.ncbi.nlm.nih.gov/pubmed/35243489 http://dx.doi.org/10.1242/dmm.049032 |