Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

The cellular level of TDP-43 (also known as TARDBP) is tightly regulated; increases or decreases in TDP-43 have deleterious effects in cells. The predominant mechanism responsible for the regulation of the level of TDP-43 is an autoregulatory negative feedback loop. In this study, we identified an i...

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Detalles Bibliográficos
Autores principales: Pacetti, Miriam, De Conti, Laura, Marasco, Luciano E., Romano, Maurizio, Rashid, Mohammad M., Nubiè, Martina, Baralle, Francisco E., Baralle, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066495/
https://www.ncbi.nlm.nih.gov/pubmed/35243489
http://dx.doi.org/10.1242/dmm.049032

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