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Monooxygenase-catalyzed regioselective hydroxylation for the synthesis of hydroxyequols

Monooxygenases exhibiting high activity and differing regioselectivity for the dietary isoflavone metabolite equol were discovered among enzymes in the HpaBC family by a genome mining approach. These enzymes enabled the one-step product-selective synthesis of 3′- and 6-hydroxyequols from equol and m...

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Detalles Bibliográficos
Autores principales: Hashimoto, Takafumi, Nozawa, Daiki, Mukai, Katsuyuki, Matsuyama, Akinobu, Kuramochi, Kouji, Furuya, Toshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066559/
https://www.ncbi.nlm.nih.gov/pubmed/35518870
http://dx.doi.org/10.1039/c9ra03913a