Population pharmacokinetic model and limited sampling strategy for clozapine using plasma and dried blood spot samples

BACKGROUND: To improve efficacy, therapeutic drug monitoring is often used in clozapine therapy. Trough level monitoring is regular, but trough levels provide limited information about the pharmacokinetics of clozapine and exposure in time. The area under the concentration time curve (AUC) is genera...

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Detalles Bibliográficos
Autores principales: Geers, Lisanne M., Cohen, Dan, Wehkamp, Laura M., van Wattum, Hans J., Kosterink, Jos G.W., Loonen, Anton J.M., Touw, Daan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066631/
https://www.ncbi.nlm.nih.gov/pubmed/35518123
http://dx.doi.org/10.1177/20451253211065857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066631/
https://www.ncbi.nlm.nih.gov/pubmed/35518123
http://dx.doi.org/10.1177/20451253211065857

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