PrP (58–93) peptide from unstructured N-terminal domain of human prion protein forms amyloid-like fibrillar structures in the presence of Zn(2+) ions

Many transition metal ions modulate the aggregation of different amyloid peptides. Substoichiometric zinc concentrations can inhibit aggregation, while an excess of zinc can accelerate the formation of cytotoxic fibrils. In this study, we report the fibrillization of the octarepeat domain to amyloid...

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Detalles Bibliográficos
Autores principales: Gielnik, Maciej, Pietralik, Zuzanna, Zhukov, Igor, Szymańska, Aneta, Kwiatek, Wojciech M., Kozak, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066832/
https://www.ncbi.nlm.nih.gov/pubmed/35519468
http://dx.doi.org/10.1039/c9ra01510h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066832/
https://www.ncbi.nlm.nih.gov/pubmed/35519468
http://dx.doi.org/10.1039/c9ra01510h

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