VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

BACKGROUND: Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or malignant tumors. The mechanism of VHL mutants in pathogenicity is poorly understan...

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Detalles Bibliográficos
Autores principales: Ma, Xueyou, Tan, Zenglai, Zhang, Qin, Ma, Kaifang, Xiao, Jun, Wang, Xiong, Wang, Yanan, Zhong, Mengjie, Wang, Yu, Li, Jing, Zeng, Xing, Guan, Wei, Wang, Shaogang, Gong, Kan, Wei, Gong-Hong, Wang, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066845/
https://www.ncbi.nlm.nih.gov/pubmed/35505422
http://dx.doi.org/10.1186/s13578-022-00790-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066845/
https://www.ncbi.nlm.nih.gov/pubmed/35505422
http://dx.doi.org/10.1186/s13578-022-00790-x

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