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TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5

BACKGROUND: Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious. METHODS: Western blotting and immunohistochemistry (IHC) assays were used to investi...

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Detalles Bibliográficos
Autores principales: Jin, Xiaoying, Wang, Dandan, Lei, Mengxia, Guo, Yan, Cui, Yuqing, Chen, Fengzhi, Sun, Weiling, Chen, Xuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066866/
https://www.ncbi.nlm.nih.gov/pubmed/35509067
http://dx.doi.org/10.1186/s12967-022-03370-2