HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation

Somatic hypermutation (SHM) produces point mutations in immunoglobulin (Ig) genes in B cells when uracils created by the activation-induced deaminase are processed in a mutagenic manner by enzymes of the base excision repair (BER) and mismatch repair (MMR) pathways. Such uracil processing creates DN...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Lizhen, Shukla, Vipul, Yadavalli, Anurupa Devi, Dinesh, Ravi K., Xu, Dijin, Rao, Anjana, Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067407/
https://www.ncbi.nlm.nih.gov/pubmed/35450882
http://dx.doi.org/10.1101/gad.349438.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067407/
https://www.ncbi.nlm.nih.gov/pubmed/35450882
http://dx.doi.org/10.1101/gad.349438.122

Ejemplares similares