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HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation

Somatic hypermutation (SHM) produces point mutations in immunoglobulin (Ig) genes in B cells when uracils created by the activation-induced deaminase are processed in a mutagenic manner by enzymes of the base excision repair (BER) and mismatch repair (MMR) pathways. Such uracil processing creates DN...

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Detalles Bibliográficos
Autores principales:	Wu, Lizhen, Shukla, Vipul, Yadavalli, Anurupa Devi, Dinesh, Ravi K., Xu, Dijin, Rao, Anjana, Schatz, David G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067407/ https://www.ncbi.nlm.nih.gov/pubmed/35450882 http://dx.doi.org/10.1101/gad.349438.122

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