BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity

PURPOSE: The solid tumor microenvironment (TME) drives T cell dysfunction and inhibits the effectiveness of immunotherapies such as chimeric antigen receptor-based T cell (CAR T) cells. Early data has shown that modulation of T cell metabolism can improve intratumoral T cell function in preclinical...

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Detalles Bibliográficos
Autores principales: Hickman, Taylor L., Choi, Eugene, Whiteman, Kathleen R., Muralidharan, Sujatha, Pai, Tapasya, Johnson, Tyler, Parikh, Avani, Friedman, Taylor, Gilbert, Madaline, Shen, Binzhang, Barron, Luke, McGinness, Kathleen E., Ettenberg, Seth A., Motz, Greg T., Weiss, Glen J., Jensen-Smith, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067639/
https://www.ncbi.nlm.nih.gov/pubmed/35507536
http://dx.doi.org/10.1371/journal.pone.0266980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067639/
https://www.ncbi.nlm.nih.gov/pubmed/35507536
http://dx.doi.org/10.1371/journal.pone.0266980

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