Design, synthesis and docking study of Vortioxetine derivatives as a SARS-CoV-2 main protease inhibitor

PURPOSE: Vortioxetine an anti-depressant FDA-drug recently reported showing better in vitro efficacy against SARS-CoV-2. METHODS: In this study, we have synthesized ten new derivatives having alkenes, alkynes, benzyl, aryl, and mixed carbamate at the N-terminal of vortioxetine. Then the binding ener...

Descripción completa

Detalles Bibliográficos
Autores principales: Suryavanshi, Hemant, Chaudhari, Raju D., Patil, Vishakha, Majumdar, Swapan, Debnath, Sudhan, Biswas, Goutam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067898/
https://www.ncbi.nlm.nih.gov/pubmed/35508799
http://dx.doi.org/10.1007/s40199-022-00441-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067898/
https://www.ncbi.nlm.nih.gov/pubmed/35508799
http://dx.doi.org/10.1007/s40199-022-00441-z

Ejemplares similares