Lack of the immune adaptor molecule SARM1 accelerates disease in prion infected mice and is associated with increased mitochondrial respiration and decreased expression of NRF2

Prion diseases are a group of fatal, transmissible neurodegenerative diseases of mammals. In the brain, axonal loss and neuronal death are prominent in prion infection, but the mechanisms remain poorly understood. Sterile alpha and heat/Armadillo motif 1 (SARM1) is a protein expressed in neurons of...

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Detalles Bibliográficos
Autores principales: Ward, Anne, Jessop, Forrest, Faris, Robert, Shoup, Daniel, Bosio, Catharine M., Peterson, Karin E., Priola, Suzette A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067904/
https://www.ncbi.nlm.nih.gov/pubmed/35507602
http://dx.doi.org/10.1371/journal.pone.0267720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067904/
https://www.ncbi.nlm.nih.gov/pubmed/35507602
http://dx.doi.org/10.1371/journal.pone.0267720

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