The essential M. tuberculosis Clp protease is functionally asymmetric in vivo

The Clp protease system is a promising, noncanonical drug target against Mycobacterium tuberculosis (Mtb). Unlike in Escherichia coli, the Mtb Clp protease consists of two distinct proteolytic subunits, ClpP1 and ClpP2, which hydrolyze substrates delivered by the chaperones ClpX and ClpC1. While bio...

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Detalles Bibliográficos
Autores principales: d’Andrea, Felipe B., Poulton, Nicholas C., Froom, Ruby, Tam, Kayan, Campbell, Elizabeth A., Rock, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067928/
https://www.ncbi.nlm.nih.gov/pubmed/35507665
http://dx.doi.org/10.1126/sciadv.abn7943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067928/
https://www.ncbi.nlm.nih.gov/pubmed/35507665
http://dx.doi.org/10.1126/sciadv.abn7943

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