α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling

Previously, we found that α-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1). Here, we demonstrated the beneficial effects of AKG on glucose homeostasis in a diet-induced obesity (DIO) mouse model, which are independent of OXGR1. We also sh...

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Detalles Bibliográficos
Autores principales: Yuan, Yexian, Zhu, Canjun, Wang, Yongliang, Sun, Jia, Feng, Jinlong, Ma, Zewei, Li, Penglin, Peng, Wentong, Yin, Cong, Xu, Guli, Xu, Pingwen, Jiang, Yuwei, Jiang, Qingyan, Shu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067931/
https://www.ncbi.nlm.nih.gov/pubmed/35507647
http://dx.doi.org/10.1126/sciadv.abn2879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067931/
https://www.ncbi.nlm.nih.gov/pubmed/35507647
http://dx.doi.org/10.1126/sciadv.abn2879

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