Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening

An efficient method for synthesising NMDAR co-agonist Sunifiram (DM235), in addition to Sunifram-carbamate and anthranilamide hybrids, has been developed in high yields via protecting group-free stepwise unsymmetric diacylation of piperazine using N-acylbenzotiazole. Compounds 3f, 3d, and 3i exhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Agha, Khalid A., Abo-Dya, Nader E., Issahaku, Abdul Rashid, Agoni, Clement, Soliman, Mahmoud E. S., Abdel-Aal, Eatedal H., Abdel-Samii, Zakaria K., Ibrahim, Tarek S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067966/
https://www.ncbi.nlm.nih.gov/pubmed/35484855
http://dx.doi.org/10.1080/14756366.2022.2068147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067966/
https://www.ncbi.nlm.nih.gov/pubmed/35484855
http://dx.doi.org/10.1080/14756366.2022.2068147

Ejemplares similares