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Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening

An efficient method for synthesising NMDAR co-agonist Sunifiram (DM235), in addition to Sunifram-carbamate and anthranilamide hybrids, has been developed in high yields via protecting group-free stepwise unsymmetric diacylation of piperazine using N-acylbenzotiazole. Compounds 3f, 3d, and 3i exhibit...

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Detalles Bibliográficos
Autores principales:	Agha, Khalid A., Abo-Dya, Nader E., Issahaku, Abdul Rashid, Agoni, Clement, Soliman, Mahmoud E. S., Abdel-Aal, Eatedal H., Abdel-Samii, Zakaria K., Ibrahim, Tarek S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067966/ https://www.ncbi.nlm.nih.gov/pubmed/35484855 http://dx.doi.org/10.1080/14756366.2022.2068147

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