Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails

Identification of highly selective type II kinase inhibitors is described. Two different chiral peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase inhibitor GNF-7 to enhance the selectivity. Kinome-wide selectivity profiling analysis showed that type II kinas...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Seo-Jung, Jung, Jae Eun, Oh, Do Hee, Kim, Minsup, Kim, Jae-Min, Chung, Kyung-Sook, Han, Hee-Soo, Lee, Jeong-Hun, Lee, Kyung-Tae, Jeong, Hee Jin, Park, In Ho, Jeon, Eunkyeong, Shin, Jeon-Soo, Hwang, Dongkeun, Cho, Art E., Lee, Duck-Hyung, Sim, Taebo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067983/
https://www.ncbi.nlm.nih.gov/pubmed/35484863
http://dx.doi.org/10.1080/14756366.2022.2068148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067983/
https://www.ncbi.nlm.nih.gov/pubmed/35484863
http://dx.doi.org/10.1080/14756366.2022.2068148

Ejemplares similares