Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds, ubiquitinates, and promotes proteasomal degradation of the RAS GTPase...

Descripción completa

Detalles Bibliográficos
Autores principales: Cuevas-Navarro, Antonio, Rodriguez-Muñoz, Laura, Grego-Bessa, Joaquim, Cheng, Alice, Rauen, Katherine A, Urisman, Anatoly, McCormick, Frank, Jimenez, Gerardo, Castel, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068208/
https://www.ncbi.nlm.nih.gov/pubmed/35467524
http://dx.doi.org/10.7554/eLife.76495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068208/
https://www.ncbi.nlm.nih.gov/pubmed/35467524
http://dx.doi.org/10.7554/eLife.76495

Ejemplares similares