Cargando…

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds, ubiquitinates, and promotes proteasomal degradation of the RAS GTPase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cuevas-Navarro, Antonio, Rodriguez-Muñoz, Laura, Grego-Bessa, Joaquim, Cheng, Alice, Rauen, Katherine A, Urisman, Anatoly, McCormick, Frank, Jimenez, Gerardo, Castel, Pau
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068208/ https://www.ncbi.nlm.nih.gov/pubmed/35467524 http://dx.doi.org/10.7554/eLife.76495

Ejemplares similares

Structural Model for Recruitment of RIT1 to the LZTR1 E3 Ligase: Evidences from an Integrated Computational Approach
por: Paladino, Antonella, et al.
Publicado: (2021)

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy
por: Cuevas-Navarro, Antonio, et al.
Publicado: (2023)

The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium
por: Grego-Bessa, Joaquim, et al.
Publicado: (2016)

LZTR1: A promising adaptor of the CUL3 family
por: Zhang, Hui, et al.
Publicado: (2021)

Autosomal Recessive Noonan Syndrome Associated with Biallelic LZTR1Variants
por: Johnston, Jennifer J., et al.
Publicado: (2018)

Delineation of dominant and recessive forms of LZTR1‐associated Noonan syndrome
por: Pagnamenta, Alistair T., et al.
Publicado: (2019)

Oncogenic RIT1 mutations in lung adenocarcinoma
por: Berger, A H, et al.
Publicado: (2014)

Targeted STAT1 therapy for LZTR1‐driven peripheral nerve sheath tumor
por: Ivanisevic, Tonci, et al.
Publicado: (2023)

The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling
por: Lopez, Jocelyne, et al.
Publicado: (2023)

LZTR1 molecular genetic overlap with clinical implications for Noonan syndrome and schwannomatosis
por: Farncombe, Kirsten M., et al.
Publicado: (2022)

Putting the Rit in cellular resistance: Rit, p38 MAPK and oxidative stress
por: Cai, Weikang, et al.
Publicado: (2013)

Bon Dieu rit : roman /
por: Saint-Amand, Edris
Publicado: (1988)

Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon
por: Talley, Mary Jo, et al.
Publicado: (2021)

RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities()
por: Wu, Lei, et al.
Publicado: (2023)

Comparison of the frequency of loss‐of‐function LZTR1 variants between schwannomatosis patients and the general population
por: Deng, Fanxuan, et al.
Publicado: (2022)

Noonan syndrome‐associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish
por: Nakagama, Yu, et al.
Publicado: (2019)

Isolation, Identification, Whole-Genome Sequencing, and Annotation of Four Bacillus Species, B. anthracis RIT375, B. circulans RIT379, B. altitudinis RIT380, and B. megaterium RIT381, from Internal Stem Tissue of the Insulin Plant Costus igneus
por: Polter, Steven J., et al.
Publicado: (2015)

Aeromonas hydrophila RIT668 and Citrobacter portucalensis RIT669—Potential Zoonotic Pathogens Isolated from Spotted Turtles
por: Thomas, Seema G., et al.
Publicado: (2020)

Isolation, Whole-Genome Sequencing, and Annotation of Three Unclassified Antibiotic-Producing Bacteria, Enterobacter sp. Strain RIT 637, Pseudomonas sp. Strain RIT 778, and Deinococcus sp. Strain RIT 780
por: Schroeter, Marissa N., et al.
Publicado: (2021)

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR
por: Yan, Wupeng, et al.
Publicado: (2020)

Spontaneous resolution of nonimmune hydrops fetalis in a fetus with TP63 gene mutation and LZTR1 gene variants
por: Hurni, Yannick, et al.
Publicado: (2021)

The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells
por: Palanivel, Chitra, et al.
Publicado: (2022)

Perspectives on metals-based radioimmunotherapy (RIT): moving forward
por: White, Jordan M., et al.
Publicado: (2021)

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
por: Vichas, Athea, et al.
Publicado: (2021)

Prenatal cases with rare RIT1 variants causing severe fetal hydrops and death
por: Miceikaite, Ieva, et al.
Publicado: (2021)

Mutation Analysis of BRAF, MEK1 and MEK2 in 15 Ovarian Cancer Cell Lines: Implications for Therapy
por: Estep, Anne L., et al.
Publicado: (2007)

IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade
por: Mir, Sajad, et al.
Publicado: (2017)

RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1
por: Meyer zum Büschenfelde, Uta, et al.
Publicado: (2018)

LZTR1‐related spinal schwannomatosis and 7q11.23 duplication syndrome: A complex phenotype with dual diagnosis
por: Muthusamy, Karthik, et al.
Publicado: (2020)

A Chinese family with Noonan syndrome caused by a heterozygous variant in LZTR1: a case report and literature review
por: Zhao, Xiu, et al.
Publicado: (2021)

A Comprehensive Pan-Cancer Analysis of the Tumorigenic Effect of Leucine-Zipper-Like Transcription Regulator (LZTR1) in Human Cancer
por: Zhou, Bo, et al.
Publicado: (2022)

Exome Survey and Candidate Gene Re-Sequencing Identifies Novel Exstrophy Candidate Genes and Implicates LZTR1 in Disease Formation
por: Köllges, Ricarda, et al.
Publicado: (2023)

Simultaneous Detection of NF1, SPRED1, LZTR1, and NF2 Gene Mutations by Targeted NGS in an Italian Cohort of Suspected NF1 Patients
por: Bianchessi, Donatella, et al.
Publicado: (2020)

Propagation of cell death in dropdead1, a sorghum ortholog of the maize lls1 mutant
por: Sindhu, Anoop, et al.
Publicado: (2018)

The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS
por: Schalch, Thomas, et al.
Publicado: (2011)

RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis
por: Feng, Yan-Fen, et al.
Publicado: (2018)

A novel RIT1 mutation causes deterioration of Noonan syndrome-associated cardiac hypertrophy
por: Cai, Jingjing, et al.
Publicado: (2019)

The blended phenotype of a germline RIT1 and a mosaic PIK3CA variant
por: Berland, Siren, et al.
Publicado: (2021)

Noonan syndrome caused by RIT1 gene mutation: A case report and literature review
por: Zha, Ping, et al.
Publicado: (2022)

Mutant SF3B1 promotes malignancy in PDAC
por: Simmler, Patrik, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l64duesn5g83pv58n28fmp86lk