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The effect of erythromycin and clarithromycin versus azithromycin on serum valproate concentration

INTRODUCTION: Unlike azithromycin, erythromycin and clarithromycin strongly inhibit CYP450, which metabolizes valproic acid. The aim of this study was to evaluate the impact of macrolide administration on serum valproate trough levels. METHODS: This retrospective cohort study included hospitalized a...

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Detalles Bibliográficos
Autores principales: Albanji, Muradi, Alshehri, Samah, Eljaaly, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068565/
https://www.ncbi.nlm.nih.gov/pubmed/35527827
http://dx.doi.org/10.1016/j.jsps.2022.02.004