Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis

Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) “difficult-to-treat”. Cartilage destruction is central to OA patho-etiology and is mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes and its deficie...

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Detalles Bibliográficos
Autores principales: Zhang, Yun, Li, Shuaijun, Jin, Peisheng, Shang, Ting, Sun, Ruizhu, Lu, Laiya, Guo, Kaijin, Liu, Jiping, Tong, Yongjuan, Wang, Junbang, Liu, Sanhong, Wang, Chen, Kang, Yubin, Zhu, Wenmin, Wang, Qian, Zhang, Xiaoren, Yin, Feng, Sun, Yi Eve, Cui, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068604/
https://www.ncbi.nlm.nih.gov/pubmed/35508470
http://dx.doi.org/10.1038/s41467-022-30119-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068604/
https://www.ncbi.nlm.nih.gov/pubmed/35508470
http://dx.doi.org/10.1038/s41467-022-30119-8

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