Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching...

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Detalles Bibliográficos
Autores principales: Ge, Rongbin, Wang, Zongwei, Cheng, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068628/
https://www.ncbi.nlm.nih.gov/pubmed/35508696
http://dx.doi.org/10.1038/s41698-022-00272-w
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author Ge, Rongbin
Wang, Zongwei
Cheng, Liang
author_facet Ge, Rongbin
Wang, Zongwei
Cheng, Liang
author_sort Ge, Rongbin
collection PubMed
description Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching related to anticancer therapies. Lastly, we summarize the challenges targeting the tumor environments, and emphasize that continued exploration of tumor heterogeneity is needed in order to offer a personalized therapy for advanced prostate cancer patients.
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spelling pubmed-90686282022-05-05 Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance Ge, Rongbin Wang, Zongwei Cheng, Liang NPJ Precis Oncol Review Article Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching related to anticancer therapies. Lastly, we summarize the challenges targeting the tumor environments, and emphasize that continued exploration of tumor heterogeneity is needed in order to offer a personalized therapy for advanced prostate cancer patients. Nature Publishing Group UK 2022-05-04 /pmc/articles/PMC9068628/ /pubmed/35508696 http://dx.doi.org/10.1038/s41698-022-00272-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Ge, Rongbin
Wang, Zongwei
Cheng, Liang
Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
title Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
title_full Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
title_fullStr Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
title_full_unstemmed Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
title_short Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
title_sort tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068628/
https://www.ncbi.nlm.nih.gov/pubmed/35508696
http://dx.doi.org/10.1038/s41698-022-00272-w
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