NMR (1)H, (13)C, (15)N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation

RAS proteins cycling between the active-form (GTP-bound) and inactive-form (GDP-bound) play a key role in cell signaling pathways that control cell survival, proliferation, and differentiation. Mutations at codon 12, 13, and 61 in RAS are known to attenuate its GTPase activity favoring the RAS activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharma, Alok K., Dyba, Marcin, Tonelli, Marco, Smith, Brian, Gillette, William K., Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Maciag, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068649/
https://www.ncbi.nlm.nih.gov/pubmed/34686998
http://dx.doi.org/10.1007/s12104-021-10050-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068649/
https://www.ncbi.nlm.nih.gov/pubmed/34686998
http://dx.doi.org/10.1007/s12104-021-10050-7

Ejemplares similares