Use of connectivity index and simple topological parameters for estimating the inhibition potency of acetylcholinesterase

Acetylcholinesterase (AChE) has proven to be an effective drug target in the treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and dementia. We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK(i), on a set of 75 structurally different compound...

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Detalles Bibliográficos
Autores principales: Miličević, Ante, Šinko, Goran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068751/
https://www.ncbi.nlm.nih.gov/pubmed/35527825
http://dx.doi.org/10.1016/j.jsps.2022.01.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068751/
https://www.ncbi.nlm.nih.gov/pubmed/35527825
http://dx.doi.org/10.1016/j.jsps.2022.01.025

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