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Use of connectivity index and simple topological parameters for estimating the inhibition potency of acetylcholinesterase
Acetylcholinesterase (AChE) has proven to be an effective drug target in the treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and dementia. We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK(i), on a set of 75 structurally different compound...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068751/ https://www.ncbi.nlm.nih.gov/pubmed/35527825 http://dx.doi.org/10.1016/j.jsps.2022.01.025 |