Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model

Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was injected subc...

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Detalles Bibliográficos
Autores principales: Tojo, Mineyuki, Miyato, Hideyo, Koinuma, Koji, Horie, Hisanaga, Tsukui, Hidenori, Kimura, Yuki, Kaneko, Yuki, Ohzawa, Hideyuki, Yamaguchi, Hironori, Yoshimura, Kotaro, Lefor, Alan Kawarai, Sata, Naohiro, Kitayama, Joji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068771/
https://www.ncbi.nlm.nih.gov/pubmed/35508498
http://dx.doi.org/10.1038/s41598-022-11236-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068771/
https://www.ncbi.nlm.nih.gov/pubmed/35508498
http://dx.doi.org/10.1038/s41598-022-11236-2

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