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Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model

Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was injected subc...

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Detalles Bibliográficos
Autores principales:	Tojo, Mineyuki, Miyato, Hideyo, Koinuma, Koji, Horie, Hisanaga, Tsukui, Hidenori, Kimura, Yuki, Kaneko, Yuki, Ohzawa, Hideyuki, Yamaguchi, Hironori, Yoshimura, Kotaro, Lefor, Alan Kawarai, Sata, Naohiro, Kitayama, Joji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068771/ https://www.ncbi.nlm.nih.gov/pubmed/35508498 http://dx.doi.org/10.1038/s41598-022-11236-2

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