Cargando…

Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF

Enhancer RNAs (eRNAs) are long non-coding RNAs that originate from enhancers. Although eRNA transcription is a canonical feature of activated enhancers, the molecular features required for eRNA function and the mechanism of how eRNAs impinge on target gene transcription have not been established. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gorbovytska, Vladyslava, Kim, Seung-Kyoon, Kuybu, Filiz, Götze, Michael, Um, Dahun, Kang, Keunsoo, Pittroff, Andreas, Brennecke, Theresia, Schneider, Lisa-Marie, Leitner, Alexander, Kim, Tae-Kyung, Kuhn, Claus-D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068813/ https://www.ncbi.nlm.nih.gov/pubmed/35508485 http://dx.doi.org/10.1038/s41467-022-29934-w

Ejemplares similares

Structure of paused transcription complex Pol II-DSIF-NELF
por: Vos, Seychelle M., et al.
Publicado: (2018)

The NELF pausing checkpoint mediates the functional divergence of Cdk9
por: DeBerardine, Michael, et al.
Publicado: (2023)

Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause Regions
por: Pagano, John M., et al.
Publicado: (2014)

RNA polymerase II pausing factor NELF in CD8(+) T cells promotes antitumor immunity
por: Wu, Bogang, et al.
Publicado: (2022)

Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes
por: Stadelmayer, Bernd, et al.
Publicado: (2014)

Molecular characterization of Drosophila NELF
por: Wu, Chwen-Huey, et al.
Publicado: (2005)

SAYP and Brahma are important for ‘repressive’ and ‘transient’ Pol II pausing
por: Vorobyeva, Nadezhda E., et al.
Publicado: (2012)

Dynamic turnover of paused Pol II complexes at human promoters
por: Erickson, Benjamin, et al.
Publicado: (2018)

ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II
por: Ohe, Seina, et al.
Publicado: (2022)

Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome
por: Kim, Seung-Kyoon, et al.
Publicado: (2021)

NELF Potentiates Gene Transcription in the Drosophila Embryo
por: Wang, Xiaoling, et al.
Publicado: (2010)

Genome-wide RNA pol II initiation and pausing in neural progenitors of the rat
por: Scheidegger, Adam, et al.
Publicado: (2019)

Release of promoter–proximal paused Pol II in response to histone deacetylase inhibition
por: Vaid, Roshan, et al.
Publicado: (2020)

RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription
por: Abuhashem, Abderhman, et al.
Publicado: (2022)

Regulation of Pol II Pausing during Daily Gene Transcription in Mouse Liver
por: Xu, Wei, et al.
Publicado: (2023)

Stress-induced nuclear condensation of NELF drives transcriptional downregulation
por: Rawat, Prashant, et al.
Publicado: (2021)

Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome
por: Nilson, Kyle A., et al.
Publicado: (2017)

BORDER proteins protect expression of neighboring genes by promoting 3′ Pol II pausing in plants
por: Yu, Xuhong, et al.
Publicado: (2019)

Evidence of slightly increased Pol II pausing in UPF1-depleted Drosophila melanogaster cells
por: Singh, Anand K, et al.
Publicado: (2020)

Coupling of co-transcriptional splicing and 3’ end Pol II pausing during termination in Arabidopsis
por: Zhou, Sixian, et al.
Publicado: (2023)

CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription
por: Laitem, Clélia, et al.
Publicado: (2015)

Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish
por: Huang, Mengling, et al.
Publicado: (2022)

Kinetics of promoter Pol II on Hsp70 reveal stable pausing and key insights into its regulation
por: Buckley, Martin S., et al.
Publicado: (2014)

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
por: Jonkers, Iris, et al.
Publicado: (2014)

Planarians recruit piRNAs for mRNA turnover in adult stem cells
por: Kim, Iana V., et al.
Publicado: (2019)

Integrator is recruited to promoter‐proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors
por: Beltran, Toni, et al.
Publicado: (2020)

Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development
por: Ramalingam, Vivekanandan, et al.
Publicado: (2023)

NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma
por: Dang, Hien, et al.
Publicado: (2019)

The negative elongation factor NELF promotes induced transcriptional response of Drosophila ecdysone-dependent genes
por: Mazina, Marina Yu., et al.
Publicado: (2021)

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
por: Zhang, Jieqiong, et al.
Publicado: (2023)

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
por: Khoueiry, P., et al.
Publicado: (2019)

EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release
por: Mukherjee, Kaustav, et al.
Publicado: (2022)

PARP inhibitor shuts down the global translation of thyroid cancer through promoting Pol II binding to DIMT1 pause
por: Hou, Xiukun, et al.
Publicado: (2023)

Prognostic Markers and Valve Therapy: To Pause or Not to Pause
por: Sorajja, Paul, et al.
Publicado: (2019)

The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies
por: Suzuki, Hidefumi, et al.
Publicado: (2022)

Role of NELF-B in supporting epithelial-mesenchymal transition and cell proliferation during hepatocellular carcinoma progression
por: Ghouraba, Mennatallah Hani, et al.
Publicado: (2021)

Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C
por: Soliman, Shimaa H. A., et al.
Publicado: (2023)

Structure of the human core transcription-export complex reveals a hub for multivalent interactions
por: Pühringer, Thomas, et al.
Publicado: (2020)

Harnessing Avidity: Quantifying the Entropic and Energetic Effects of Linker Length and Rigidity for Multivalent Binding of Antibodies to HIV-1
por: Einav, Tal, et al.
Publicado: (2019)

NELFE promoted pancreatic cancer metastasis and the epithelial-to-mesenchymal transition by decreasing the stabilization of NDRG2 mRNA
por: Han, Lili, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uop9b88uarqu4jg9qpebf81gg5