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Identification of Potent and Selective JAK1 Lead Compounds Through Ligand-Based Drug Design Approaches
JAK1 plays a significant role in the intracellular signaling by interacting with cytokine receptors in different types of cells and is linked to the pathogenesis of various cancers and in the pathology of the immune system. In this study, ligand-based pharmacophore modeling combined with virtual scr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068899/ https://www.ncbi.nlm.nih.gov/pubmed/35529449 http://dx.doi.org/10.3389/fphar.2022.837369 |