Identification of Potent and Selective JAK1 Lead Compounds Through Ligand-Based Drug Design Approaches

JAK1 plays a significant role in the intracellular signaling by interacting with cytokine receptors in different types of cells and is linked to the pathogenesis of various cancers and in the pathology of the immune system. In this study, ligand-based pharmacophore modeling combined with virtual scr...

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Detalles Bibliográficos
Autores principales: Babu, Sathya, Nagarajan, Santhosh Kumar, Sathish, Sruthy, Negi, Vir Singh, Sohn, Honglae, Madhavan, Thirumurthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068899/
https://www.ncbi.nlm.nih.gov/pubmed/35529449
http://dx.doi.org/10.3389/fphar.2022.837369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068899/
https://www.ncbi.nlm.nih.gov/pubmed/35529449
http://dx.doi.org/10.3389/fphar.2022.837369

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