Discovery and development of brain-penetrant (18)F-labeled radioligands for neuroimaging of the sigma-2 receptors

We have discovered and synthesized a series of indole-based derivatives as novel sigma-2 (σ(2)) receptor ligands. Two ligands with high σ(2) receptor affinity and subtype selectivity were then radiolabeled with F-18 in good radiochemical yields and purities, and evaluated in rodents. In biodistribut...

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Detalles Bibliográficos
Autores principales: Zhang, Ying, Wang, Tao, Zhang, Xiaojun, Deuther-Conrad, Winnie, Fu, Hualong, Cui, Mengchao, Zhang, Jinming, Brust, Peter, Huang, Yiyun, Jia, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069315/
https://www.ncbi.nlm.nih.gov/pubmed/35530149
http://dx.doi.org/10.1016/j.apsb.2021.08.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069315/
https://www.ncbi.nlm.nih.gov/pubmed/35530149
http://dx.doi.org/10.1016/j.apsb.2021.08.029

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