Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer

Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this protein–protein interaction (PPI) may offer promisi...

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Detalles Bibliográficos
Autores principales: Cheng, Sha-Sha, Qu, Yuan-Qing, Wu, Jia, Yang, Guan-Jun, Liu, Hao, Wang, Wanhe, Huang, Qi, Chen, Feng, Li, Guodong, Wong, Chun-Yuen, Wong, Vincent Kam Wai, Ma, Dik-Lung, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069406/
https://www.ncbi.nlm.nih.gov/pubmed/35530158
http://dx.doi.org/10.1016/j.apsb.2021.10.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069406/
https://www.ncbi.nlm.nih.gov/pubmed/35530158
http://dx.doi.org/10.1016/j.apsb.2021.10.024

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