A novel E198K substitution in the PA gene of influenza A virus with reduced susceptibility to baloxavir acid

Baloxavir acid (BXA), the active compound in baloxavir marboxil (BXM), reduces the propagation of influenza A and B viruses by inhibiting the cap-dependent endonuclease activity of the polymerase acidic (PA) subunit. Although BXM has been used to treat influenza virus infections, recently, there has...

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Detalles Bibliográficos
Autores principales: Takizawa, Naoki, Momose, Fumitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069958/
https://www.ncbi.nlm.nih.gov/pubmed/35511288
http://dx.doi.org/10.1007/s00705-022-05456-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069958/
https://www.ncbi.nlm.nih.gov/pubmed/35511288
http://dx.doi.org/10.1007/s00705-022-05456-0

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