Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide

CONTEXT: Rare homozygous or biallelic variants in POMC, PCSK1, and LEPR can disrupt signaling through the melanocortin-4 receptor (MC4R) pathway, resulting in hyperphagia and severe early-onset obesity. In pivotal Phase 3 clinical trials, treatment with the MC4R agonist setmelanotide reduced hunger...

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Detalles Bibliográficos
Autores principales: Wabitsch, Martin, Farooqi, Sadaf, Flück, Christa E, Bratina, Natasa, Mallya, Usha G, Stewart, Murray, Garrison, Jill, van den Akker, Erica, Kühnen, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Clinical Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070354/
https://www.ncbi.nlm.nih.gov/pubmed/35528826
http://dx.doi.org/10.1210/jendso/bvac057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070354/
https://www.ncbi.nlm.nih.gov/pubmed/35528826
http://dx.doi.org/10.1210/jendso/bvac057

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