Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals

[Image: see text] Chemical-induced alteration of maternal thyroid hormone levels may increase the risk of adverse neurodevelopmental outcomes in offspring. US federal risk assessments rely almost exclusively on apical endpoints in animal models for deriving points of departure (PODs). New approach m...

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Detalles Bibliográficos
Autores principales: Carlson, Jeffrey M., Janulewicz, Patricia A., Kleinstreuer, Nicole C., Heiger-Bernays, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070357/
https://www.ncbi.nlm.nih.gov/pubmed/35446564
http://dx.doi.org/10.1021/acs.est.1c07143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070357/
https://www.ncbi.nlm.nih.gov/pubmed/35446564
http://dx.doi.org/10.1021/acs.est.1c07143

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